Israeli researchers find discovery in war against brain cancer - study

• Published date: 06 October 2021
• Author: JERUSALEM POST STAFF
• Publication title: Jerusalem Post, The: Web Edition Articles (Israel)

The findings of the study, which were published in the journal Cell Reports, showed that there are immune system cells that, despite the fact that their primary function is to attack and kill the cancer cells, actually act as "double agents" that increase and intensify the aggressiveness and threat of the tumor.

Glioblastoma is one of the most deadly types of cancer, with the average life expectancy of patients being about 12 to 15 months from the moment of detection.

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The researchers noted that typically, the scientific monitoring of the development of the cancerous tumor in animal models is carried out without an active immune system, in order to enable the absorption and growth of cancer cells in the body. The disadvantage of this commonly-used model lies in the fact that the immune system either does not exist or does not function properly, which prevents researchers from monitoring the interaction between it and the tumor cells.

The study, which was conducted at TAU in Dr. Dinorah Friedmann-Morvinski's laboratory, used a model that examined the development of cancer cells in animal models with functioning immune systems. This allowed the cancer to grow gradually, to the point of the development of a massive tumor...