Investigadores israelíes e italianos sugieren intervención en las primeras etapas del Alzheimer
Published date | 25 March 2024 |
Author | JUDY SIEGEL-ITZKOVICH |
Publication title | Jerusalem Post, The: Web Edition Articles (Israel) |
La agregación de proteínas mal plegadas es la causa fundamental de muchas condiciones degenerativas, incluyendo el Alzheimer, la enfermedad de Parkinson y la diabetes tipo 2.
Durante las últimas tres décadas, los tratamientos convencionales para el Alzheimer han sido en su mayoría ineficaces, en gran parte porque se centran en combatir la forma fibrilar (en forma de varilla) de A-beta. Sin embargo, la investigación emergente sugiere que la forma oligomérica soluble de A-beta representa la mayor amenaza para la salud de las neuronas (células nerviosas), lo que conduce al deterioro cognitivo y la neurotoxicidad.
Un avance reciente en el tratamiento proviene del desarrollo de un anticuerpo capaz de reconocer tanto las formas oligoméricas como fibrilares de A-beta, ofreciendo una nueva esperanza al campo, según el Prof. Shai Rahimipour del departamento de química de la Universidad Bar-Ilan (BIU) en Ramat Gan, junto con los científicos italianos Profesores Angelo Monguzzi y Marcello Campione de la Universidad de Milano-Bicocca. La terapia innovadora ha demostrado resultados prometedores en retrasar la progresión de la enfermedad hasta en un 36% en individuos con deterioro cognitivo leve a moderado.
Su estudio, financiado en parte por el Ministerio de Ciencia y Tecnología de Israel, acaba de ser publicado en la revista Advanced Healthcare Materials bajo el título "Tratamiento no invasivo del Alzheimer con nanotubos centelleantes".
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